A 34-year-old man, who is positive for human immunodeficiency virus (HIV) and a resident of the Ohio-Mississippi River valleys region, developed a systemic illness characterized by hepatosplenomegaly and generalized lymphadenopathy. Which of the following microscopic descriptions of organisms from a resected lesion is most consistent with a presumptive diagnosis of disseminated histoplasmosis?
A. Budding yeast forms surrounded by empty halos
B. Cup-shaped forms demonstrable by silver stain within a foamy amorphous intra-alveolar exudate
C. Intracavitary mycelial forms
D. Minute fungal yeast forms within phagocytes
E. Thick-walled spherules filled with endospores